Protein name:
Lysyl oxidase homolog 2 ;
Alternative:
Lysyl oxidase-like protein 2 ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and probably specifically mediates deamination of histone H3. Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
Subcellular Location:
Secreted
Extracellular space
Extracellular matrix
Basement membrane
Nucleus
Chromosome
Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.
Protein Attributes:
50:
MEGFLGFNHN | HCFIVLFFVS | LSLAQYEHWP | YLPGYPEPPP | QVYQPPRRPA |
100:
DVPKIQLRLA | GQKRKHNEGR | VEVFYNGEWG | TVCDDDFSIH | AAHVICRELG |
150:
YVEAVSWLPS | SKYGKGEGKI | WMDNVHCNGK | EATLAACTSN | GWGVTDCKHT |
200:
EDVGVVCSEK | RIPGFKFDNS | LLNQIENMNI | QVEDIRIRPI | LATYRKRVPV |
250:
TEGYVEVKDE | GTWKQICDKH | WTMKNSRVVC | GMFGFPSERK | YNTKVYKMFA |
300:
SRRKQHYWAY | SMDCTGNEAH | ISSCKLGNHL | NVDTEKNATC | DNGMPAVASC |
350:
VPGRAFAPSS | HSGFRKAFRQ | EQPLVRLKGG | ANTGEGRVEV | LKNGEWGTVC |
400:
DDNWNLVSAS | VVCRELGFGS | AKEAITGARL | GQGMGPIHLN | EIDCTGFEKS |
450:
LTDCKFNMES | QGCNHEEDAA | VRCNVPAMGF | QNQLRLVGGR | NPYEGRVEVL |
500:
AERNGTLRWG | TVCSQGWSTV | EAMVVCRQLG | LGFASHAFQE | TWYWHGDVSA |
550:
DSVVMSGVKC | SGTEMSLAHC | RHDGADVSCP | RGGGRFGAGV | SCSETAPDLV |
600:
LNAELVEQTA | YLEDRPMFML | QCAQEENCLA | SSAVNTSVTS | GYRRLLRFSS |
650:
QIHNNGQSDF | RPKNGRHAWV | WHDCHRHYHS | MEVFTHYDLL | NLNGTKVAEG |
700:
HKASFCLEDT | ECEADVQKQY | ECANFGEQGI | TVGCWDVYRH | DIDCQWIDIT |
750:
DVPPGDYLFQ | VVINPNYEVA | ESDYSNNVMK | CRSRYDGQRI | WMYNSVHNGA |
774:
NQDGDTEERF | SAYWKLGNSI | LFSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Chicken
Rat
Mouse
ELISA Kit for Chicken Lysyl oxidase homolog 2
ELISA Kit for Chicken Lysyl oxidase homolog 2
ELISA Kit for Chicken Lysyl oxidase homolog 2
ELISA Kit for Chicken Lysyl oxidase homolog 2
ELISA Kit for Chicken Lysyl oxidase homolog 2
CLIA Kit for Chicken Lysyl oxidase homolog 2
CLIA Kit for Chicken Lysyl oxidase homolog 2
CLIA Kit for Chicken Lysyl oxidase homolog 2
CLIA Kit for Chicken Lysyl oxidase homolog 2
CLIA Kit for Chicken Lysyl oxidase homolog 2
Polyclonal Antibody for Chicken Lysyl oxidase homolog 2
Polyclonal Antibody for Chicken Lysyl oxidase homolog 2
Polyclonal Antibody for Chicken Lysyl oxidase homolog 2
Polyclonal Antibody for Chicken Lysyl oxidase homolog 2
Polyclonal Antibody for Chicken Lysyl oxidase homolog 2
Monoclonal Antibody for Chicken Lysyl oxidase homolog 2
Monoclonal Antibody for Chicken Lysyl oxidase homolog 2
Monoclonal Antibody for Chicken Lysyl oxidase homolog 2
Monoclonal Antibody for Chicken Lysyl oxidase homolog 2
Monoclonal Antibody for Chicken Lysyl oxidase homolog 2
Protein for Chicken Lysyl oxidase homolog 2
Protein for Chicken Lysyl oxidase homolog 2
Protein for Chicken Lysyl oxidase homolog 2
Protein for Chicken Lysyl oxidase homolog 2
Protein for Chicken Lysyl oxidase homolog 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature432:695-716(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Red jungle fowl .